Archive for February, 2011


Insulin resistance is the bane of the excess carbohydrate diet!

When excess carbohydrates are chronically ingested, the insulin receptors in the brain lose their ability to mediate the anorexigenic signal properly! this is the essence of insulin resistance. Thus, your brain does not get a good signal to stop eating!

The result is catastrophic! Because the anorexigenic signal is not encoded properly, you eat more. And if you eat more carbohydrates, well, then you make more insulin which causes a further increase in insulin resistance! Thus the signal to stop eating is lost! Thus you eat more. This cycle is only going to stop when carbohydrate intake is reduced.

 

 

Ghrelin

Ghrelin is released by cells in the stomach to get you to eat more.

Perhaps you were once a fine citizen of the US and discovered that tetrahydrocannabinoid, the active ingredient in marijuana, was a great way to make yourself eat! Via the CB1 receptor mediated mechanism, THC caused you to get the munchies.

It turns out that our favorite fruit sugar and 1/2 of table sugar (sucrose), in the form of fructose, can cause you to do the same as well by activating the same CB1/endocannabinoid pathway.

This suggests that fructose consumers will overeat! The ingestion of fructose and the subsequent cascade in the brain to release endocannabinoids would cause the fructose consumer to overeat!

Indeed, I will be commenting on several positive feedback cycles that can result in overeating! All of these pathways center around excess carbohydrate consumption in one form or another.

Dr D

Erlanson-Albertsson, C. and A. Lindqvist (2010). “Fructose affects enzymes involved in the synthesis and degradation of hypothalamic endocannabinoids.” Regul Pept 161(1-3): 87-91.

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