Perhaps you were once a fine citizen of the US and discovered that tetrahydrocannabinoid, the active ingredient in marijuana, was a great way to make yourself eat! Via the CB1 receptor mediated mechanism, THC caused you to get the munchies.

It turns out that our favorite fruit sugar and 1/2 of table sugar (sucrose), in the form of fructose, can cause you to do the same as well by activating the same CB1/endocannabinoid pathway.

This suggests that fructose consumers will overeat! The ingestion of fructose and the subsequent cascade in the brain to release endocannabinoids would cause the fructose consumer to overeat!

Indeed, I will be commenting on several positive feedback cycles that can result in overeating! All of these pathways center around excess carbohydrate consumption in one form or another.

Dr D

Erlanson-Albertsson, C. and A. Lindqvist (2010). “Fructose affects enzymes involved in the synthesis and degradation of hypothalamic endocannabinoids.” Regul Pept 161(1-3): 87-91.