Welcome to Appetite Regulation. This is the professional blogging of Dr. David C. Pendergrass of the University of Kansas. I teach graduate and upper undergraduate courses in biochemistry, physiology and neurobiology. Additionally, I have written a nutrition program called “The Smartest Loser” for weight loss. I offer a seminar about the neuroregulation of appetite.

Hundreds of signals from the ingestion of food, as well as inputs from higher brain regions and endocrine tissues regulate appetite in an area of the brain called the hypothalamus. I will comment on how these signals work together as we explore the role of the macronutrients: carbohydrates, proteins and fats, as well as micronutrients, on satiety. I encourage your questions as we explore how these signals differ based upon the type of diets that are currently in use, including the Standard American Diet. I will compare these diet in terms of appetite regulation.

And for what? To regulate your appetite!

You see, the body is unbelievably remarkable in it’s ability to tell you to look for food and to tell you you’ve had enough! The signals that tell you to eat are called orexigenic signals. The signals that tell you stop eat are referred to as anorexigenic signals!

On the surface this seems to be pretty straightforward: To eat or not to eat. That’s the question! But the reality is that the signals involve some pretty important pathways in your brain that involve your mood, your food intake, the type of food intake and even the pathways involved in rewards and addiction! Lots and lots of inputs can alter how your body perceives food!

I shall have quite an interesting time trying to figure this all out for you!

When appropriate I will also issue podcasts to forward your understanding of how the brain processes food.

I look forward to your questions and challenges in the spirit of science inquiry.


David “Dr. D” Pendergrass